Girard topped Struthers 56-39 in the WKBN Game of the Week Friday night.
Austin Claussell led the Indians with a game-high 21 points. Matt Payich added 13 points, while Christian Graziano added 8 points in the win.
Kevin Traylor led Struthers with 11 points, while Carson Ryan also reached double-figures with 10.
Girard improves to 7-3 on the campaign. The Indians will host South Range Tuesday night.
Struthers drops to 4-6 on the season. The Wildcats host Niles on Tuesday night.